Neuromelanin-sensitive imaging in patients with idiopathic rapid eye movement sleep behaviour disorder

Neuromelanin-sensitive imaging in patients with idiopathic rapid eye movement sleep behaviour disorder.

Rapid eye movement behaviour disorder.

A 70-year-old man was referred to a specialist sleep service in December 2010 by his general practitioner at the prompting of his wife. He reported a 7–8-year history of near-nightly, increasingly severe sleep disturbance with vivid dreams which would occur in the latter half of the night. Bedclothes were often found strewn around the room, and he would wake in unusual positions. The dreams usu...

Consistent abnormalities in metabolic network activity in idiopathic rapid eye movement sleep behaviour disorder.

Rapid eye movement sleep behaviour disorder has been evaluated using Parkinson's disease-related metabolic network. It is unknown whether this disorder is itself associated with a unique metabolic network. 18F-fluorodeoxyglucose positron emission tomography was performed in 21 patients (age 65.0±5.6 years) with idiopathic rapid eye movement sleep behaviour disorder and 21 age/gender-matched hea...

Markers of neurodegeneration in idiopathic rapid eye movement sleep behaviour disorder and Parkinson's disease.

Idiopathic rapid eye movement sleep behaviour disorder is an important risk factor in the development of Parkinson's disease. Numerous potential predictive markers of Parkinson's disease may present before motor symptoms emerge, but testing of these markers in rapid eye movement sleep behaviour disorder has been performed only in small studies. There has been no comparison of markers between pa...

Rapid-eye-movement sleep behaviour disorder and neurodegenerative diseases.

Rapid-eye-movement (REM) sleep behaviour disorder (RBD) is characterised by loss of muscular atonia and prominent motor behaviours during REM sleep. RBD can cause sleep disruption and severe injuries for the patient or bed partner. The disorder is strongly associated with neurodegenerative diseases, such as multiple-system atrophy, Parkinson's disease, dementia with Lewy bodies, and progressive...